Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine?
Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine?
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
The deprotection step is crucial in order to secure a good quality product in Fmoc solid phase peptide synthesis. 9-Fluorenylmethoxycarbonyl (Fmoc) removal is achieved by a two-step mechanism reaction favored by the use of cyclic secondary amines; however, the efficiency of the reaction could be affected by side reactions and by-product formation....
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Full title
Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine?
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TN_cdi_doaj_primary_oai_doaj_org_article_f67e144ef06748e98636a56357b7d898
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f67e144ef06748e98636a56357b7d898
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules21111542
