Germline T cell receptor exchange results in physiological T cell development and function
Germline T cell receptor exchange results in physiological T cell development and function
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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T cell receptor (TCR) transgenic mice represent an invaluable tool to study antigen-specific immune responses. In the pre-existing models, a monoclonal TCR is driven by a non-physiologic promoter and randomly integrated into the genome. Here, we create a highly efficient methodology to develop T cell receptor exchange (TRex) mice, in which TCRs, sp...
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Full title
Germline T cell receptor exchange results in physiological T cell development and function
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TN_cdi_doaj_primary_oai_doaj_org_article_f686ccd3ae77471d8e50f4e9b637e5d1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f686ccd3ae77471d8e50f4e9b637e5d1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36180-1
