LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multip...
LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multiple cancer types
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Author / Creator
Brown, Landon C , Tucker, Matthew D , Sedhom, Ramy , Schwartz, Eric B , Zhu, Jason , Kao, Chester , Labriola, Matthew K , Gupta, Rajan T , Marin, Daniele , Wu, Yuan , Gupta, Santosh , Zhang, Tian , Harrison, Michael R , George, Daniel J , Alva, Ajjai , Antonarakis, Emmanuel S and Armstrong, Andrew J
Publisher
England: BMJ Publishing Group LTD
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Language
English
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Publisher
England: BMJ Publishing Group LTD
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Contents
BackgroundLow-density lipoprotein receptor-related protein 1b (encoded by LRP1B) is a putative tumor suppressor, and preliminary evidence suggests LRP1B-mutated cancers may have improved outcomes with immune checkpoint inhibitors (ICI).MethodsWe conducted a multicenter, retrospective pan-cancer analysis of patients with LRP1B alterations treated wi...
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Full title
LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multiple cancer types
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TN_cdi_doaj_primary_oai_doaj_org_article_f6c317e45ad243c18c3fdb3ae41b8601
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f6c317e45ad243c18c3fdb3ae41b8601
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2020-001792
