Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition
Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The mechanistic target of rapamycin (mTOR) is a kinase whose activation is associated with poor prognosis in pre-B cell acute lymphoblastic leukemia (B-ALL). These and other findings have prompted diverse strategies for targeting mTOR signaling in B-ALL and other B-cell malignancies. In cellular models of Philadelphia Chromosome-positive (Ph+) B-AL...
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Full title
Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition
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TN_cdi_doaj_primary_oai_doaj_org_article_f6da06c10adf41ed853a873822db0706
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f6da06c10adf41ed853a873822db0706
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-00950-y
