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Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion chann...

Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion chann...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f7013bc495364bc4bcb0878e0dba41ad

Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

About this item

Full title

Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

Publisher

England: Nature Portfolio

Journal title

Communications biology, 2021-12, Vol.4 (1), p.1347-10

Language

English

Formats

Publication information

Publisher

England: Nature Portfolio

More information

Scope and Contents

Contents

The dire need for COVID-19 treatments has inspired strategies of repurposing approved drugs. Amantadine has been suggested as a candidate, and cellular as well as clinical studies have indicated beneficial effects of this drug. We demonstrate that amantadine and hexamethylene-amiloride (HMA), but not rimantadine, block the ion channel activity of P...

Alternative Titles

Full title

Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_f7013bc495364bc4bcb0878e0dba41ad

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f7013bc495364bc4bcb0878e0dba41ad

Other Identifiers

ISSN

2399-3642

E-ISSN

2399-3642

DOI

10.1038/s42003-021-02866-9

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