Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepato...
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress
About this item
Full title
Author / Creator
Zhang, Xiaodong , Li, Yan , Ma, Yingbo , Yang, Liang , Wang, Tao , Meng, Xin , Zong, Zhihong , Sun, Xun , Hua, Xiangdong and Li, Hangyu
Publisher
England: BioMed Central
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central
Subjects
More information
Scope and Contents
Contents
Hypoxia-inducible factor 1α (HIF-1α) is essential in hepatocellular carcinoma (HCC) glycolysis and progression. Yes-associated protein (YAP) is a powerful regulator and is overexpressed in many cancers, including HCC. The regulatory mechanism of YAP and HIF-1α in HCC glycolysis is unknown.
We detected YAP expression in 54 matched HCC tissues and...
Alternative Titles
Full title
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f70540bc2cde44439154b05a1d701f2c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f70540bc2cde44439154b05a1d701f2c
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-018-0892-2
