CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune...
CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Patients with locally/regionally advanced melanoma were treated with neoadjuvant combination immunotherapy with high-dose interferon α-2b (HDI) and ipilimumab in a phase I clinical trial. Tumor specimens were obtained prior to the initiation of neoadjuvant therapy, at the time of surgery and progression if available. In this study, gene expression...
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CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma
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TN_cdi_doaj_primary_oai_doaj_org_article_f7345cfe4dac4613b0bb7a5b6e8e8a42
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f7345cfe4dac4613b0bb7a5b6e8e8a42
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0245287
