NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer
NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer
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Author / Creator
Ngule, Chrispus , Shi, Ruyi , Ren, Xingcong , Jia, Hongyan , Oyelami, Felix , Li, Dong , Park, Younhee , Kim, Jinhwan , Hemati, Hami , Zhang, Yi , Xiong, Xiaofang , Shinkle, Andrew , Vanderford, Nathan L. , Bachert, Sara , Zhou, Binhua P. , Wang, Jianlong , Song, Jianxun , Liu, Xia and Yang, Jin-Ming
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Triple negative breast cancer (TNBC) is a particularly lethal breast cancer (BC) subtype driven by cancer stem cells (CSCs) and an immunosuppressive microenvironment. Our study reveals that nucleus accumbens associated protein 1 (NAC1), a member of the BTB/POZ gene family, plays a crucial role in TNBC by maintaining tumor stemness and influencing m...
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Full title
NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f74140f6f5a14ff3a6bfa413df989010
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f74140f6f5a14ff3a6bfa413df989010
Other Identifiers
ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-024-02102-y
