Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conser...
Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer mortality by 2030. Bulk transcriptomic analyses have distinguished ‘classical’ from ‘basal-like’ tumors with more aggressive clinical behavior. We derive PDAC organoids from 18 primary tumors and two matched liver metastases, and show that ‘classical’ and...
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Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
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TN_cdi_doaj_primary_oai_doaj_org_article_f77b80eb08eb4c0a93db5169bb083e64
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f77b80eb08eb4c0a93db5169bb083e64
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26059-4
