Sphingomyelin metabolism underlies Ras excitability for efficient cell migration and chemotaxis
Sphingomyelin metabolism underlies Ras excitability for efficient cell migration and chemotaxis
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Japan: Japan Society for Cell Biology
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Language
English
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Japan: Japan Society for Cell Biology
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In eukaryotic motile cells, the active Ras (Ras-GTP)-enriched domain is generated in an asymmetric manner on the cell membrane through the excitable dynamics of an intracellular signaling network. This asymmetric Ras signaling regulates pseudopod formation for both spontaneous random migration and chemoattractant-induced directional migration. Whil...
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Full title
Sphingomyelin metabolism underlies Ras excitability for efficient cell migration and chemotaxis
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TN_cdi_doaj_primary_oai_doaj_org_article_f7aa895b712642c68ddbbfacb2389233
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f7aa895b712642c68ddbbfacb2389233
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ISSN
0386-7196,1347-3700
E-ISSN
1347-3700
DOI
10.1247/csf.23045
