Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors
Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors
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Author / Creator
López, Lucía , Morosi, Luciano Gastón , La Terza, Federica , Bourdely, Pierre , Rospo, Giuseppe , Amadio, Roberto , Piperno, Giulia Maria , Russo, Valentina , Volponi, Camilla , Vodret, Simone , Joshi, Sonal , Giannese, Francesca , Lazarevic, Dejan , Germano, Giovanni , Stoitzner, Patrizia , Bardelli, Alberto , Dalod, Marc , Pace, Luigia , Caronni, Nicoletta , Guermonprez, Pierre and Benvenuti, Federica
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T cell responses to model antigens, in various tumor settings. However, the impact of cross-presenting cDC1 and the potential of DC-based therapies in tumors carrying varied levels of bona-fide neoantigens (neoAgs) remain unclear. Here we develop a hypermutate...
Alternative Titles
Full title
Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors
Authors, Artists and Contributors
Author / Creator
Morosi, Luciano Gastón
La Terza, Federica
Bourdely, Pierre
Rospo, Giuseppe
Amadio, Roberto
Piperno, Giulia Maria
Russo, Valentina
Volponi, Camilla
Vodret, Simone
Joshi, Sonal
Giannese, Francesca
Lazarevic, Dejan
Germano, Giovanni
Stoitzner, Patrizia
Bardelli, Alberto
Dalod, Marc
Pace, Luigia
Caronni, Nicoletta
Guermonprez, Pierre
Benvenuti, Federica
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f7c6a9ff87e544acbdd02715c577e12b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f7c6a9ff87e544acbdd02715c577e12b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-46685-y
