O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis
O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis
About this item
Full title
Author / Creator
Soria, Leandro R. , Makris, Georgios , D’Alessio, Alfonso M. , De Angelis, Angela , Boffa, Iolanda , Pravata, Veronica M. , Rüfenacht, Véronique , Attanasio, Sergio , Nusco, Edoardo , Arena, Paola , Ferenbach, Andrew T. , Paris, Debora , Cuomo, Paola , Motta, Andrea , Nitzahn, Matthew , Lipshutz, Gerald S. , Martínez-Pizarro, Ainhoa , Richard, Eva , Desviat, Lourdes R. , Häberle, Johannes , van Aalten, Daan M. F. and Brunetti-Pierri, Nicola
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Life-threatening hyperammonemia occurs in both inherited and acquired liver diseases affecting ureagenesis, the main pathway for detoxification of neurotoxic ammonia in mammals. Protein O-GlcNAcylation is a reversible and nutrient-sensitive post-translational modification using as substrate UDP-GlcNAc, the end-product of hexosamine biosynthesis pat...
Alternative Titles
Full title
O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis
Authors, Artists and Contributors
Author / Creator
Makris, Georgios
D’Alessio, Alfonso M.
De Angelis, Angela
Boffa, Iolanda
Pravata, Veronica M.
Rüfenacht, Véronique
Attanasio, Sergio
Nusco, Edoardo
Arena, Paola
Ferenbach, Andrew T.
Paris, Debora
Cuomo, Paola
Motta, Andrea
Nitzahn, Matthew
Lipshutz, Gerald S.
Martínez-Pizarro, Ainhoa
Richard, Eva
Desviat, Lourdes R.
Häberle, Johannes
van Aalten, Daan M. F.
Brunetti-Pierri, Nicola
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f7dd4ac66ee843bca09996d7cef4b0de
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f7dd4ac66ee843bca09996d7cef4b0de
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32904-x
