Structural insights into epitope-paratope interactions of a monoclonal antibody targeting CEACAM5-ex...
Structural insights into epitope-paratope interactions of a monoclonal antibody targeting CEACAM5-expressing tumors
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are overexpressed in some tumor types. The antibody-drug conjugate tusamitamab ravtansine specifically recognizes the A3-B3 domains of human CEACAM5 (hCEACAM5). To understand this specificity, here we map the epitope-paratope interface between the A3-B3 domains of hCEACAM5 (hCEACAM5...
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Full title
Structural insights into epitope-paratope interactions of a monoclonal antibody targeting CEACAM5-expressing tumors
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TN_cdi_doaj_primary_oai_doaj_org_article_f7fbe31decc84f1998df3899e41251c7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f7fbe31decc84f1998df3899e41251c7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-53746-9
