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The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α...

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f81d485b302d454596333e69beb5f6bc

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

About this item

Full title

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

Publisher

London: Nature Publishing Group UK

Journal title

EMBO molecular medicine, 2014-10, Vol.6 (10), p.1328-1346

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Estetrol (E
4
) is a natural estrogen with a long half‐life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand‐binding domain bound to 17β‐estradiol (E
2
) and E
4
are very similar, as well as their capacity to activate the two activation functions AF‐1 and AF‐2...

Alternative Titles

Full title

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_f81d485b302d454596333e69beb5f6bc

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f81d485b302d454596333e69beb5f6bc

Other Identifiers

ISSN

1757-4676,1757-4684

E-ISSN

1757-4684

DOI

10.15252/emmm.201404112

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