Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote mic...
Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice
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England: BioMed Central
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English
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England: BioMed Central
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During inflammatory demyelination, TNF receptor 1 (TNFR1) mediates detrimental proinflammatory effects of soluble TNF (solTNF), whereas TNFR2 mediates beneficial effects of transmembrane TNF (tmTNF) through oligodendroglia, microglia, and possibly other cell types. This model supports the use of selective inhibitors of solTNF/TNFR1 as anti-inflamma...
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Full title
Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice
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TN_cdi_doaj_primary_oai_doaj_org_article_f835375dd4814f7eb875ab3d9fd3f00f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f835375dd4814f7eb875ab3d9fd3f00f
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ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-021-02200-4
