DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor
DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor
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Author / Creator
Pandiloski, Ninoslav , Horváth, Vivien , Karlsson, Ofelia , Koutounidou, Symela , Dorazehi, Fereshteh , Christoforidou, Georgia , Matas-Fuentes, Jon , Gerdes, Patricia , Garza, Raquel , Jönsson, Marie E. , Adami, Anita , Atacho, Diahann A. M. , Johansson, Jenny G. , Englund, Elisabet , Kokaia, Zaal , Jakobsson, Johan and Douse, Christopher H.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The human silencing hub (HUSH) complex binds to transcripts of LINE-1 retrotransposons (L1s) and other genomic repeats, recruiting MORC2 and other effectors to remodel chromatin. How HUSH and MORC2 operate alongside DNA methylation, a central epigenetic regulator of repeat transcription, remains largely unknown. Here we interrogate this relationshi...
Alternative Titles
Full title
DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor
Authors, Artists and Contributors
Author / Creator
Horváth, Vivien
Karlsson, Ofelia
Koutounidou, Symela
Dorazehi, Fereshteh
Christoforidou, Georgia
Matas-Fuentes, Jon
Gerdes, Patricia
Garza, Raquel
Jönsson, Marie E.
Adami, Anita
Atacho, Diahann A. M.
Johansson, Jenny G.
Englund, Elisabet
Kokaia, Zaal
Jakobsson, Johan
Douse, Christopher H.
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f87b719d040b4e7fb2c512a1ad18871b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f87b719d040b4e7fb2c512a1ad18871b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-50765-4
