PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibr...
PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Fibrosis due to extracellular matrix (ECM) secretion from myofibroblasts complicates many chronic liver diseases causing scarring and organ failure. Integrin-dependent interaction with scar ECM promotes pro-fibrotic features. However, the pathological intracellular mechanism in liver myofibroblasts is not completely understood, and further insight...
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Full title
PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
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TN_cdi_doaj_primary_oai_doaj_org_article_f88a909827dd4238bbf8364f30631af2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f88a909827dd4238bbf8364f30631af2
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12502
