A stress-dependent TDP-43 SUMOylation program preserves neuronal function
A stress-dependent TDP-43 SUMOylation program preserves neuronal function
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England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are overwhelmingly linked to TDP-43 dysfunction. Mutations in TDP-43 are rare, indicating that the progressive accumulation of exogenous factors – such as cellular stressors – converge on TDP-43 to play a key role in disease pathogenesis. Post translational modifications such as...
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Full title
A stress-dependent TDP-43 SUMOylation program preserves neuronal function
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TN_cdi_doaj_primary_oai_doaj_org_article_f8b068c31f7b41ca9b7b15e4a678e32d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f8b068c31f7b41ca9b7b15e4a678e32d
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-025-00826-z
