Structural and functional consequences of the STAT5BN642H driver mutation
Structural and functional consequences of the STAT5BN642H driver mutation
About this item
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Author / Creator
de Araujo, Elvin D. , Erdogan, Fettah , Neubauer, Heidi A. , Meneksedag-Erol, Deniz , Manaswiyoungkul, Pimyupa , Eram, Mohammad S. , Seo, Hyuk-Soo , Qadree, Abdul K. , Israelian, Johan , Orlova, Anna , Suske, Tobias , Pham, Ha T. T. , Boersma, Auke , Tangermann, Simone , Kenner, Lukas , Rülicke, Thomas , Dong, Aiping , Ravichandran, Manimekalai , Brown, Peter J. , Audette, Gerald F. , Rauscher, Sarah , Dhe-Paganon, Sirano , Moriggl, Richard , Gunning, Patrick T. and Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Hyper-activated STAT5B variants are high value oncology targets for pharmacologic intervention. STAT5B
N642H
, a frequently-occurring oncogenic driver mutation, promotes aggressive T-cell leukemia/lymphoma in patient carriers, although the molecular origins remain unclear. Herein, we emphasize the aggressive nature of STAT5B
N642H
in dr...
Alternative Titles
Full title
Structural and functional consequences of the STAT5BN642H driver mutation
Authors, Artists and Contributors
Author / Creator
Erdogan, Fettah
Neubauer, Heidi A.
Meneksedag-Erol, Deniz
Manaswiyoungkul, Pimyupa
Eram, Mohammad S.
Seo, Hyuk-Soo
Qadree, Abdul K.
Israelian, Johan
Orlova, Anna
Suske, Tobias
Pham, Ha T. T.
Boersma, Auke
Tangermann, Simone
Kenner, Lukas
Rülicke, Thomas
Dong, Aiping
Ravichandran, Manimekalai
Brown, Peter J.
Audette, Gerald F.
Rauscher, Sarah
Dhe-Paganon, Sirano
Moriggl, Richard
Gunning, Patrick T.
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f8b672c48f8f4b91911646f53ce84f0b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f8b672c48f8f4b91911646f53ce84f0b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10422-7
