MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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G protein-coupled receptor (GPCR) signalling, including that involving apelin (APLN) and its receptor APLNR, is known to be important in vascular development. How this ligand–receptor pair regulates the downstream signalling cascades in this context remains poorly understood. Here, we show that mice with
Apln, Aplnr
or endothelial-specific
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MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
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TN_cdi_doaj_primary_oai_doaj_org_article_f8d99b3209af438b97ff65e526d3b632
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f8d99b3209af438b97ff65e526d3b632
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11268
