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The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertr...

The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertr...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f8f5c01d0099483396ec497c3588065b

The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertranscription

About this item

Full title

The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertranscription

Publisher

London: Nature Publishing Group UK

Journal title

Communications biology, 2023-11, Vol.6 (1), p.1174-15, Article 1174

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

TAZ::CAMTA1 is a fusion protein found in over 90% of Epithelioid Hemangioendothelioma (EHE), a rare vascular sarcoma with an unpredictable disease course. To date, how TAZ::CAMTA1 initiates tumour formation remains unexplained. To study the oncogenic mechanism leading to EHE initiation, we developed a model system whereby TAZ::CAMTA1 expression is...

Alternative Titles

Full title

The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertranscription

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_f8f5c01d0099483396ec497c3588065b

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f8f5c01d0099483396ec497c3588065b

Other Identifiers

ISSN

2399-3642

E-ISSN

2399-3642

DOI

10.1038/s42003-023-05540-4

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