Synthesis, Biological Evaluation, and In Silico Studies of New Acetylcholinesterase Inhibitors Based...
Synthesis, Biological Evaluation, and In Silico Studies of New Acetylcholinesterase Inhibitors Based on Quinoxaline Scaffold
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Basel: MDPI AG
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Language
English
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Basel: MDPI AG
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A quinoxaline scaffold exhibits various bioactivities in pharmacotherapeutic interests. In this research, twelve quinoxaline derivatives were synthesized and evaluated as new acetylcholinesterase inhibitors. We found all compounds showed potent inhibitory activity against acetylcholinesterase (AChE) with IC50 values of 0.077 to 50.080 µM, along wit...
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Full title
Synthesis, Biological Evaluation, and In Silico Studies of New Acetylcholinesterase Inhibitors Based on Quinoxaline Scaffold
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TN_cdi_doaj_primary_oai_doaj_org_article_f91ef760e13344489c04caa5eb690855
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f91ef760e13344489c04caa5eb690855
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules26164895
