Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and...
Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Herein, we studied the impact of empty LNP (eLNP), component of mRNA-based vaccine, on anti-viral pathways and immune function of cells from young and aged individuals. eLNP induced maturation of monocyte derived dendritic cells (MDDCs). We further show that eLNP upregulated CD40 and induced cytokine production in multiple DC subsets and monocytes....
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Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals
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TN_cdi_doaj_primary_oai_doaj_org_article_f939a91eb95f4c4fb669b5245aa1ee19
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f939a91eb95f4c4fb669b5245aa1ee19
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-023-04555-1
