A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism
A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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A diastereoselective synthesis of the title compound as a single
E
diastereomer has been efficiently accomplished by assembling the featured pyrano-indole scaffold of the spiro[cyclohexane-dihydropyrano[3,4-b]-indole]-amine framework through an oxa-Pictet-Spengler reaction, promoted by a cheap and green Zeolite catalyst. Basic pharmacological...
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A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism
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TN_cdi_doaj_primary_oai_doaj_org_article_f9793336055c4632b76511f6e3164571
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f9793336055c4632b76511f6e3164571
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-02502-9
