UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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p62/SQSTM1 is known to act as a key mediator in the selective autophagy of protein aggregates, or aggrephagy, by steering ubiquitinated protein aggregates towards the autophagy pathway. Here, we use a yeast two-hybrid screen to identify the prefoldin-like chaperone UXT as an interacting protein of p62. We show that UXT can bind to protein aggregate...
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UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
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TN_cdi_doaj_primary_oai_doaj_org_article_f97d34af557c40b1a93c7c19606cff1c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f97d34af557c40b1a93c7c19606cff1c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22252-7
