The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptoti...
The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Ferroptosis is a caspase-independent form of regulated cell death strongly linked to the accumulation of reactive lipid hydroperoxides. Lipid hydroperoxides are neutralized in cells by glutathione peroxidase 4 (GPX4) and inhibitors of GPX4 are potent ferroptosis inducers with therapeutic potential in cancer. Here we report that siRNA-mediated silen...
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The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells
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TN_cdi_doaj_primary_oai_doaj_org_article_f9948a2b8d6a47e68b1bfd8ea6baab82
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f9948a2b8d6a47e68b1bfd8ea6baab82
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2058-7716
E-ISSN
2058-7716
DOI
10.1038/s41420-022-01044-y
