Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner
Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions. However, persistent repression has been difficult to achieve in a predictable manner using targeted systems.
Here, we...
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Full title
Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner
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TN_cdi_doaj_primary_oai_doaj_org_article_f99d86a8bbaf4fed912b9c90925d2dd9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f99d86a8bbaf4fed912b9c90925d2dd9
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ISSN
1756-8935
E-ISSN
1756-8935
DOI
10.1186/s13072-019-0275-8
