Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus
Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus
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United States: Elsevier Inc
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Language
English
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Publisher
United States: Elsevier Inc
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Contents
Through the action of two virus-encoded decapping enzymes (D9 and D10) that remove protective caps from mRNA 5′-termini, Vaccinia virus (VACV) accelerates mRNA decay and limits activation of host defenses. D9- or D10-deficient VACV are markedly attenuated in mice and fail to counter cellular double-stranded RNA-responsive innate immune effectors, i...
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Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus
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TN_cdi_doaj_primary_oai_doaj_org_article_f9c143d1a07a48b2b4911e9999f79dea
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f9c143d1a07a48b2b4911e9999f79dea
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ISSN
2372-7705
E-ISSN
2372-7705
DOI
10.1016/j.omto.2018.01.001
