Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects o...
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels
About this item
Full title
Author / Creator
Roth Flach, Rachel J. , Bollinger, Eliza , Reyes, Allan R. , Laforest, Brigitte , Kormos, Bethany L. , Liu, Shenping , Reese, Matthew R. , Martinez Alsina, Luis A. , Buzon, Leanne , Zhang, Yuan , Bechle, Bruce , Rosado, Amy , Sahasrabudhe, Parag V. , Knafels, John , Bhattacharya, Samit K. , Omoto, Kiyoyuki , Stansfield, John C. , Hurley, Liam D. , Song, LouJin , Luo, Lina , Breitkopf, Susanne B. , Monetti, Mara , Cunio, Teresa , Tierney, Brendan , Geoly, Frank J. , Delmore, Jake , Siddall, C. Parker , Xue, Liang , Yip, Ka N. , Kalgutkar, Amit S. , Miller, Russell A. , Zhang, Bei B. and Filipski, Kevin J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step in BCAA degradation, the activity of which is inhibited by BCKDH kinase (BDK)-mediated phosphorylation. Screening efforts to discover BDK inhibitors led to identification of t...
Alternative Titles
Full title
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels
Authors, Artists and Contributors
Author / Creator
Bollinger, Eliza
Reyes, Allan R.
Laforest, Brigitte
Kormos, Bethany L.
Liu, Shenping
Reese, Matthew R.
Martinez Alsina, Luis A.
Buzon, Leanne
Zhang, Yuan
Bechle, Bruce
Rosado, Amy
Sahasrabudhe, Parag V.
Knafels, John
Bhattacharya, Samit K.
Omoto, Kiyoyuki
Stansfield, John C.
Hurley, Liam D.
Song, LouJin
Luo, Lina
Breitkopf, Susanne B.
Monetti, Mara
Cunio, Teresa
Tierney, Brendan
Geoly, Frank J.
Delmore, Jake
Siddall, C. Parker
Xue, Liang
Yip, Ka N.
Kalgutkar, Amit S.
Miller, Russell A.
Zhang, Bei B.
Filipski, Kevin J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f9d9823491ce46a3808353f3a122b4ab
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f9d9823491ce46a3808353f3a122b4ab
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40536-y
