Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impair...
Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice
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Liang, Yusheng , kang, Xu , Zhang, Haiwang , Xu, Heng and Wu, Xian
Publisher
London: BioMed Central Ltd
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English
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London: BioMed Central Ltd
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Background Previously we reported that inhibition of GPR17 prevents amyloid [beta] 1-42 (A[beta].sub.1-42)-induced cognitive impairment in mice. However, the role of GPR17 on cognition is still largely unknown. Methods Herein, we used a mouse model of cognitive impairment induced by lipopolysaccharide (LPS) to further investigate the role of GPR17...
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Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice
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TN_cdi_doaj_primary_oai_doaj_org_article_f9f54a1f50874b149e0ccc67b9dd00a8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f9f54a1f50874b149e0ccc67b9dd00a8
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ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-023-02958-9
