Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in i...
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors
About this item
Full title
Author / Creator
Castiglioni, Alessandra , Yang, Yagai , Williams, Katherine , Gogineni, Alvin , Lane, Ryan S. , Wang, Amber W. , Shyer, Justin A. , Zhang, Zhe , Mittman, Stephanie , Gutierrez, Alan , Astarita, Jillian L. , Thai, Minh , Hung, Jeffrey , Yang, Yeqing Angela , Pourmohamad, Tony , Himmels, Patricia , De Simone, Marco , Elstrott, Justin , Capietto, Aude-Hélène , Cubas, Rafael , Modrusan, Zora , Sandoval, Wendy , Ziai, James , Gould, Stephen E. , Fu, Wenxian , Wang, Yulei , Koerber, James T. , Sanjabi, Shomyseh , Mellman, Ira , Turley, Shannon J. and Müller, Sören
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
TGFβ signaling is associated with non-response to immune checkpoint blockade in patients with advanced cancers, particularly in the immune-excluded phenotype. While previous work demonstrates that converting tumors from excluded to inflamed phenotypes requires attenuation of PD-L1 and TGFβ signaling, the underlying cellular mechanisms remain unclea...
Alternative Titles
Full title
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors
Authors, Artists and Contributors
Author / Creator
Yang, Yagai
Williams, Katherine
Gogineni, Alvin
Lane, Ryan S.
Wang, Amber W.
Shyer, Justin A.
Zhang, Zhe
Mittman, Stephanie
Gutierrez, Alan
Astarita, Jillian L.
Thai, Minh
Hung, Jeffrey
Yang, Yeqing Angela
Pourmohamad, Tony
Himmels, Patricia
De Simone, Marco
Elstrott, Justin
Capietto, Aude-Hélène
Cubas, Rafael
Modrusan, Zora
Sandoval, Wendy
Ziai, James
Gould, Stephen E.
Fu, Wenxian
Wang, Yulei
Koerber, James T.
Sanjabi, Shomyseh
Mellman, Ira
Turley, Shannon J.
Müller, Sören
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fa5b40b8c1aa4ad3abed292446b9c3af
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fa5b40b8c1aa4ad3abed292446b9c3af
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40398-4
