Hypermethylation of CDKN2A CpG island drives resistance to PRC2 inhibitors in SWI/SNF loss-of-functi...
Hypermethylation of CDKN2A CpG island drives resistance to PRC2 inhibitors in SWI/SNF loss-of-function tumors
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Wang, Xinghao , Wang, Yajun , Xie, Min , Ma, Shichao , Zhang, Yilin , Wang, Lele , Ge, Yangfeng , Li, Guobin , Zhao, Mengxi , Chen, Sheng , Yan, Chenxi , Zhang, Hailong and Sun, Wei
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Polycomb repressive complex 2 (PRC2) catalyzes the writing of the tri-methylated histone H3 at Lys27 (H3K27me3) epigenetic marker and suppresses the expression of genes, including tumor suppressors. The function of the complex can be partially antagonized by the SWI/SNF chromatin-remodeling complex. Previous studies have suggested that PRC2 is impo...
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Full title
Hypermethylation of CDKN2A CpG island drives resistance to PRC2 inhibitors in SWI/SNF loss-of-function tumors
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TN_cdi_doaj_primary_oai_doaj_org_article_fa83a36325fc447abd2d3ff4a8da87d8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fa83a36325fc447abd2d3ff4a8da87d8
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-024-07109-3
