FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis
FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis
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Author / Creator
Mitchell, Allison V. , Wu, Ling , James Block, C. , Zhang, Mu , Hackett, Justin , Craig, Douglas B. , Chen, Wei , Zhao, Yongzhong , Zhang, Bin , Dang, Yongjun , Zhang, Xiaohong , Zhang, Shengping , Wang, Chuangui , Gibson, Heather , Pile, Lori A. , Kidder, Benjamin , Matherly, Larry , Yang, Zhe , Dou, Yali and Wu, Guojun
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Aberrant expression of the Forkhead box transcription factor, FOXQ1, is a prevalent mechanism of epithelial-mesenchymal transition (EMT) and metastasis in multiple carcinoma types. However, it remains unknown how FOXQ1 regulates gene expression. Here, we report that FOXQ1 initiates EMT by recruiting the MLL/KMT2 histone methyltransferase complex as...
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Full title
FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis
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TN_cdi_doaj_primary_oai_doaj_org_article_fb2c929fd9f444428d14613bbb55b90c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fb2c929fd9f444428d14613bbb55b90c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34239-z
