Loss of function of the nuclear envelope protein LEMD2 causes DNA damage–dependent cardiomyopathy
Loss of function of the nuclear envelope protein LEMD2 causes DNA damage–dependent cardiomyopathy
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United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Mutations in nuclear envelope proteins (NEPs) cause devastating genetic diseases, known as envelopathies, that primarily affect the heart and skeletal muscle. A mutation in the NEP LEM domain-containing protein 2 (LEMD2) causes severe cardiomyopathy in humans. However, the roles of LEMD2 in the heart and the pathological mechanisms responsible for...
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Full title
Loss of function of the nuclear envelope protein LEMD2 causes DNA damage–dependent cardiomyopathy
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TN_cdi_doaj_primary_oai_doaj_org_article_fbc0f2db436f472f8bc0e6a56d395731
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fbc0f2db436f472f8bc0e6a56d395731
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI158897
