Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef In...
Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors
About this item
Full title
Author / Creator
He, Xinheng , Huang, Ning , Qiu, Yuran , Zhang, Jian , Liu, Yaqin , Yin, Xiao-Lan and Lu, Shaoyong
Publisher
Switzerland: MDPI
Journal title
Language
English
Formats
Publication information
Publisher
Switzerland: MDPI
Subjects
More information
Scope and Contents
Contents
Metastasis is the major cause of death in colorectal cancer and it has been proven that inhibiting an interaction between adenomatous polyposis coli (APC) and Rho guanine nucleotide exchange factor 4 (Asef) efficaciously restrain metastasis. However, current inhibitors cannot achieve a satisfying effect in vivo and need to be optimized. In the pres...
Alternative Titles
Full title
Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fbd845a3ea8c4cbcb678a759dd82fae1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fbd845a3ea8c4cbcb678a759dd82fae1
Other Identifiers
ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules26040962
