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Intron retention is a robust marker of intertumoral heterogeneity in pancreatic ductal adenocarcinom...

Intron retention is a robust marker of intertumoral heterogeneity in pancreatic ductal adenocarcinom...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fc3a0c8629c1439484ba57658f1cc672

Intron retention is a robust marker of intertumoral heterogeneity in pancreatic ductal adenocarcinoma

About this item

Full title

Intron retention is a robust marker of intertumoral heterogeneity in pancreatic ductal adenocarcinoma

Publisher

London: Nature Publishing Group UK

Journal title

Npj genomic medicine, 2020-12, Vol.5 (1), p.55-17, Article 55

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a 5-year survival rate of <8%. Unsupervised clustering of 76 PDAC patients based on intron retention (IR) events resulted in two clusters of tumors (IR-1 and IR-2). While gene expression-based clusters are not predictive of patient outcome in this cohort, the clusters we developed...

Alternative Titles

Full title

Intron retention is a robust marker of intertumoral heterogeneity in pancreatic ductal adenocarcinoma

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_fc3a0c8629c1439484ba57658f1cc672

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fc3a0c8629c1439484ba57658f1cc672

Other Identifiers

ISSN

2056-7944

E-ISSN

2056-7944

DOI

10.1038/s41525-020-00159-4

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