Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
About this item
Full title
Author / Creator
Farr, Joshua N. , Saul, Dominik , Doolittle, Madison L. , Kaur, Japneet , Rowsey, Jennifer L. , Vos, Stephanie J. , Froemming, Mitchell N. , Lagnado, Anthony B. , Zhu, Yi , Weivoda, Megan , Ikeno, Yuji , Pignolo, Robert J. , Niedernhofer, Laura J. , Robbins, Paul D. , Jurk, Diana , Passos, João F. , LeBrasseur, Nathan K. , Tchkonia, Tamara , Kirkland, James L. , Monroe, David G. and Khosla, Sundeep
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) that allowed for inducible SnC elimination (senolysis) in a cell-specific manner and compared the effe...
Alternative Titles
Full title
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
Authors, Artists and Contributors
Author / Creator
Saul, Dominik
Doolittle, Madison L.
Kaur, Japneet
Rowsey, Jennifer L.
Vos, Stephanie J.
Froemming, Mitchell N.
Lagnado, Anthony B.
Zhu, Yi
Weivoda, Megan
Ikeno, Yuji
Pignolo, Robert J.
Niedernhofer, Laura J.
Robbins, Paul D.
Jurk, Diana
Passos, João F.
LeBrasseur, Nathan K.
Tchkonia, Tamara
Kirkland, James L.
Monroe, David G.
Khosla, Sundeep
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fc80a778d0594c49a7d28805675dc1fe
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fc80a778d0594c49a7d28805675dc1fe
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI162519
