NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axi...
NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis
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Author / Creator
Yin, Bing , Qian, Baolin , Yu, Hongjun , Ke, Shanjia , Li, Zihao , Hua, Yongliang , Lu, Shounan , Wang, Chaoqun , Li, Mengxin , Guo, Sixun , Li, Zhongyu , Zhou, Yongzhi , Meng, Zhanzhi , Li, Xinglong , Xu, Yanan , Feng, Zhigang , Bai, Miaoyu , Fu, Yao , Tang, Wei , Hong, Shangyu and Ma, Yong
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Hepatic ischemia‒reperfusion injury (HIRI) occurs during liver surgery, contributing to postoperative complications such as liver failure, prolonged hospital stays, and increased morbidity and mortality rates. Yet, the mechanism underlying HIRI remains unclear. Nicotinamide N-methyltransferase (NNMT) facilitates the conversion of nicotinamide into...
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Full title
NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis
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TN_cdi_doaj_primary_oai_doaj_org_article_fc813847da574232b8d9050b5a8f9dc5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fc813847da574232b8d9050b5a8f9dc5
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-59968-9
