LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through mo...
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
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Author / Creator
Cirnaru, Maria D. , Marte, Antonella , Belluzzi, Elisa , Russo, Isabella , Gabrielli, Martina , Longo, Francesco , Arcuri, Ludovico , Murru, Luca , Bubacco, Luigi , Matteoli, Michela , Fedele, Ernesto , Sala, Carlo , Passafaro, Maria , Morari, Michele , Greggio, Elisa , Onofri, Franco and Piccoli, Giovanni
Publisher
Switzerland: Frontiers Research Foundation
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Language
English
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Publisher
Switzerland: Frontiers Research Foundation
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Scope and Contents
Contents
Mutations in Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson's disease (PD). LRRK2 is a complex protein that consists of multiple domains executing several functions, including GTP hydrolysis, kinase activity, and protein binding. Robust evidence suggests that LRRK2 acts at the synaptic site as a molecu...
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Full title
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
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TN_cdi_doaj_primary_oai_doaj_org_article_fc81bc2378104db58a48beabcd795f47
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fc81bc2378104db58a48beabcd795f47
Other Identifiers
ISSN
1662-5099
E-ISSN
1662-5099
DOI
10.3389/fnmol.2014.00049
