Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colit...
Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release
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Author / Creator
Wu, Jin , Cai, Wei , Xu, Congfeng , Zhou, Jiefei , Wang, Lingyu , Tian, Chunyan , Du, Xixi , Gong, Zizhen , Zhao, Shengnan and Chen, Yingwei
Publisher
Cairo, Egypt: Hindawi Publishing Corporation
Journal title
Language
English
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Publisher
Cairo, Egypt: Hindawi Publishing Corporation
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Contents
We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate NLRP3 inflammasome and thus contributes to the development of inflammatory bowel disease (IBD). Moreover, the effect of DCA on inflammasome activation is mainly mediated through bile acid receptor sphin...
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Full title
Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fc8dc2093bbd40028b615d61b1ca91e1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fc8dc2093bbd40028b615d61b1ca91e1
Other Identifiers
ISSN
2314-8861
E-ISSN
2314-7156
DOI
10.1155/2018/2481418
