Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistan...
Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistance and metabolic regulation
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Author / Creator
Tao, Zhiwei , Zou, Pingan , Yang, Zhengxu , Xiong, Tao , Deng, Zhi and Chen, Qincan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Osteosarcoma (OS) presents significant treatment challenges due to chemoresistance. This study explores the molecular mechanisms underlying chemoresistance in OS, focusing on the novel fusion gene RPS27-RPS24. Using single-cell multi-omics techniques, we identified a significant upregulation of RPS27-RPS24 in chemoresistant OS cells. Our analyses r...
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Full title
Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistance and metabolic regulation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fc9ab2ca54d1494f840ea371b005aa6b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fc9ab2ca54d1494f840ea371b005aa6b
Other Identifiers
ISSN
2058-7716
E-ISSN
2058-7716
DOI
10.1038/s41420-025-02487-9
