Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor...
Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model
About this item
Full title
Author / Creator
Lau, Sai Ping , van Montfoort, Nadine , Kinderman, Priscilla , Lukkes, Melanie , Klaase, Larissa , van Nimwegen, Menno , van Gulijk, Mandy , Dumas, Jasper , Mustafa, Dana A M , Lievense, Sanne L A , Groeneveldt, Christianne , Stadhouders, Ralph , Li, Yunlei , Stubbs, Andrew , Marijt, Koen A , Vroman, Heleen , van der Burg, Sjoerd H , Aerts, Joachim , van Hall, Thorbald , Dammeijer, Floris and van Eijck, Casper H J
Publisher
England: BMJ Publishing Group Ltd
Journal title
Language
English
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Publication information
Publisher
England: BMJ Publishing Group Ltd
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More information
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Contents
BackgroundPancreatic ductal adenocarcinoma (PDAC) is notoriously resistant to treatment including checkpoint-blockade immunotherapy. We hypothesized that a bimodal treatment approach consisting of dendritic cell (DC) vaccination to prime tumor-specific T cells, and a strategy to reprogram the desmoplastic tumor microenvironment (TME) would be neede...
Alternative Titles
Full title
Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model
Authors, Artists and Contributors
Author / Creator
van Montfoort, Nadine
Kinderman, Priscilla
Lukkes, Melanie
Klaase, Larissa
van Nimwegen, Menno
van Gulijk, Mandy
Dumas, Jasper
Mustafa, Dana A M
Lievense, Sanne L A
Groeneveldt, Christianne
Stadhouders, Ralph
Li, Yunlei
Stubbs, Andrew
Marijt, Koen A
Vroman, Heleen
van der Burg, Sjoerd H
Aerts, Joachim
van Hall, Thorbald
Dammeijer, Floris
van Eijck, Casper H J
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fcc1c02eafcf484f8030eee2c0fa88a7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fcc1c02eafcf484f8030eee2c0fa88a7
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2020-000772
