Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethaliti...
Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation
About this item
Full title
Author / Creator
Ford, Kyle , Munson, Brenton P. , Fong, Samson H. , Panwala, Rebecca , Chu, Wai Keung , Rainaldi, Joseph , Plongthongkum, Nongluk , Arunachalam, Vinayagam , Kostrowicki, Jarek , Meluzzi, Dario , Kreisberg, Jason F. , Jensen-Pergakes, Kristen , VanArsdale, Todd , Paul, Thomas , Tamayo, Pablo , Zhang, Kun , Bienkowska, Jadwiga , Mali, Prashant and Ideker, Trey
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cell-cycle control is accomplished by cyclin-dependent kinases (CDKs), motivating extensive research into CDK targeting small-molecule drugs as cancer therapeutics. Here we use combinatorial CRISPR/Cas9 perturbations to uncover an extensive network of functional interdependencies among CDKs and related factors, identifying 43 synthetic-lethal and 1...
Alternative Titles
Full title
Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation
Authors, Artists and Contributors
Author / Creator
Munson, Brenton P.
Fong, Samson H.
Panwala, Rebecca
Chu, Wai Keung
Rainaldi, Joseph
Plongthongkum, Nongluk
Arunachalam, Vinayagam
Kostrowicki, Jarek
Meluzzi, Dario
Kreisberg, Jason F.
Jensen-Pergakes, Kristen
VanArsdale, Todd
Paul, Thomas
Tamayo, Pablo
Zhang, Kun
Bienkowska, Jadwiga
Mali, Prashant
Ideker, Trey
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fcd5b895626948aba19a440f77fb4bf1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fcd5b895626948aba19a440f77fb4bf1
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-33329-2
