Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody...
Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen neutralisation and complement activation. It is also underrepresented as an immunotherapeutic candidate, partly due to a lack of structural information. Here, we use cryoEM to solve structures o...
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Full title
Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains
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TN_cdi_doaj_primary_oai_doaj_org_article_fcdc499f722c4bd9aa23f3e4ee0d4314
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fcdc499f722c4bd9aa23f3e4ee0d4314
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39788-5
