Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activit...
Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood. Here, we assayed the binding of five essential TFs over multiple stages of embryogenesis in two distant
species (with 1.4 substitutions per neutral...
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Full title
Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity
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TN_cdi_doaj_primary_oai_doaj_org_article_fce93f30087a461aa37aed06d6e5aa2d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fce93f30087a461aa37aed06d6e5aa2d
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.28440
