Brain change trajectories in healthy adults correlate with Alzheimer’s related genetic variation and...
Brain change trajectories in healthy adults correlate with Alzheimer’s related genetic variation and memory decline across life
About this item
Full title
Author / Creator
Roe, James M. , Vidal-Piñeiro, Didac , Sørensen, Øystein , Grydeland, Håkon , Leonardsen, Esten H. , Iakunchykova, Olena , Pan, Mengyu , Mowinckel, Athanasia , Strømstad, Marie , Nawijn, Laura , Milaneschi, Yuri , Andersson, Micael , Pudas, Sara , Bråthen, Anne Cecilie Sjøli , Kransberg, Jonas , Falch, Emilie Sogn , Øverbye, Knut , Kievit, Rogier A. , Ebmeier, Klaus P. , Lindenberger, Ulman , Ghisletta, Paolo , Demnitz, Naiara , Boraxbekk, Carl-Johan , Drevon, Christian A. , Penninx, Brenda , Bertram, Lars , Nyberg, Lars , Walhovd, Kristine B. , Fjell, Anders M. , Wang, Yunpeng , Alzheimer’s Disease Neuroimaging Initiative , the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing , Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing , Alzheimer's Disease Neuroimaging Initiative , Faculty of Medicine , Medicinska fakulteten , Strategiska forskningsområden (SFO) , Institutionen för kliniska vetenskaper, Malmö , Strategic research areas (SRA) , Lunds universitet , Profilområden och andra starka forskningsmiljöer , Cardiovascular Research - Translational Studies , Lund University , Kardiovaskulär forskning - translationella studier , EXODIAB: Excellence of Diabetes Research in Sweden , Profile areas and other strong research environments and Department of Clinical Sciences, Malmö
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Throughout adulthood and ageing our brains undergo structural loss in an average pattern resembling faster atrophy in Alzheimer’s disease (AD). Using a longitudinal adult lifespan sample (aged 30-89; 2–7 timepoints) and four polygenic scores for AD, we show that change in AD-sensitive brain features correlates with genetic AD-risk and memory declin...
Alternative Titles
Full title
Brain change trajectories in healthy adults correlate with Alzheimer’s related genetic variation and memory decline across life
Authors, Artists and Contributors
Author / Creator
Vidal-Piñeiro, Didac
Sørensen, Øystein
Grydeland, Håkon
Leonardsen, Esten H.
Iakunchykova, Olena
Pan, Mengyu
Mowinckel, Athanasia
Strømstad, Marie
Nawijn, Laura
Milaneschi, Yuri
Andersson, Micael
Pudas, Sara
Bråthen, Anne Cecilie Sjøli
Kransberg, Jonas
Falch, Emilie Sogn
Øverbye, Knut
Kievit, Rogier A.
Ebmeier, Klaus P.
Lindenberger, Ulman
Ghisletta, Paolo
Demnitz, Naiara
Boraxbekk, Carl-Johan
Drevon, Christian A.
Penninx, Brenda
Bertram, Lars
Nyberg, Lars
Walhovd, Kristine B.
Fjell, Anders M.
Wang, Yunpeng
Alzheimer’s Disease Neuroimaging Initiative
the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
Alzheimer's Disease Neuroimaging Initiative
Faculty of Medicine
Medicinska fakulteten
Strategiska forskningsområden (SFO)
Institutionen för kliniska vetenskaper, Malmö
Strategic research areas (SRA)
Lunds universitet
Profilområden och andra starka forskningsmiljöer
Cardiovascular Research - Translational Studies
Lund University
Kardiovaskulär forskning - translationella studier
EXODIAB: Excellence of Diabetes Research in Sweden
Profile areas and other strong research environments
Department of Clinical Sciences, Malmö
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fd02026c4f3c4f76979b1449b60d7bd1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fd02026c4f3c4f76979b1449b60d7bd1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-53548-z
How to access this item
ERROR: Invalid URL specified.
