Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
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Publisher
England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases. However, the mechanisms elicited by impaired lysosomal acidification remain poorly understood. We show here that inhibition of lysosomal acidification triggers cellular iron deficiency, which...
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Full title
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
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TN_cdi_doaj_primary_oai_doaj_org_article_fd107a889da64064b712d694b9b3d129
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fd107a889da64064b712d694b9b3d129
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.51031
