SMPDL3b modulates insulin receptor signaling in diabetic kidney disease
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease
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Author / Creator
Mitrofanova, A. , Mallela, S. K. , Ducasa, G. M. , Yoo, T. H. , Rosenfeld-Gur, E. , Zelnik, I. D. , Molina, J. , Varona Santos, J. , Ge, M. , Sloan, A. , Kim, J. J. , Pedigo, C. , Bryn, J. , Volosenco, I. , Faul, C. , Zeidan, Y. H. , Garcia Hernandez, C. , Mendez, A. J. , Leibiger, I. , Burke, G. W. , Futerman, A. H. , Barisoni, L. , Ishimoto, Y. , Inagi, R. , Merscher, S. and Fornoni, A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insulin receptor isoforms binding t...
Alternative Titles
Full title
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease
Authors, Artists and Contributors
Author / Creator
Mallela, S. K.
Ducasa, G. M.
Yoo, T. H.
Rosenfeld-Gur, E.
Zelnik, I. D.
Molina, J.
Varona Santos, J.
Ge, M.
Sloan, A.
Kim, J. J.
Pedigo, C.
Bryn, J.
Volosenco, I.
Faul, C.
Zeidan, Y. H.
Garcia Hernandez, C.
Mendez, A. J.
Leibiger, I.
Burke, G. W.
Futerman, A. H.
Barisoni, L.
Ishimoto, Y.
Inagi, R.
Merscher, S.
Fornoni, A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_fd12f6a07e0c479dbcdbe26fe66e7a72
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fd12f6a07e0c479dbcdbe26fe66e7a72
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10584-4
