Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and...
Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer’s disease pathogenesis. The endogenous inhibitor of this enzyme, cystatin B (
CSTB)
is encoded on chromosome 21. Thus, individuals who have Down syndrome, a genetic condition caused by having an additional copy of chromosome 21, have an extra copy of an end...
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Full title
Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
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TN_cdi_doaj_primary_oai_doaj_org_article_fdd398815b864621914e2872780af98c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fdd398815b864621914e2872780af98c
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-023-01632-8
