Structural and mechanistic insights into Quinolone Synthase to address its functional promiscuity
Structural and mechanistic insights into Quinolone Synthase to address its functional promiscuity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Quinolone synthase from
Aegle marmelos
(AmQNS) is a type III polyketide synthase that yields therapeutically effective quinolone and acridone compounds. Addressing the structural and molecular underpinnings of AmQNS and its substrate interaction in terms of its high selectivity and specificity can aid in the development of numerous novel comp...
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Structural and mechanistic insights into Quinolone Synthase to address its functional promiscuity
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TN_cdi_doaj_primary_oai_doaj_org_article_fde470523d074468b6b3cff521f42f9c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fde470523d074468b6b3cff521f42f9c
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-024-06152-2
